College Directory

Martha Belury

Professor, Endo, Diabetes & Metabolism
Professor, Human Sciences Administration
Professor, COPH -Environmental Health Sci

Program Area: Human Nutrition

(614) 292-1680
belury.1@osu.edu

Personal Website

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Biography

Professor; Carol S. Kennedy Professor of Nutrition
The Department of Human Sciences
The Ohio State University
Website at Ohio State

Education

  • University of Texas, Austin, TX in 1987, BS, Nutrition
  • University of Texas, Austin, TX in 1992, PhD, Biological Sciences

Areas of Expertise

  • The study of whole body energy metabolism as regulated by interactions between adipose, liver and muscle tissues
    • Canonical mechanisms of energy metabolism involve insulin-dependent and insulin–independent pathways in each of these tissues
    • Adipose secretes adipokines that regulate metabolism and inflammation in non-adipose tissues
  • How the availability or lack of availability of energy substrates and bioactive compounds (e.g., adipokines and dietary components) modulate metabolism and tissue function of adipose and muscle
  • Energy deprivation induces atrophy of muscle and adipose using some overlapping mechanisms including altered metabolism, inflammation, proteolysis and cell death-associated signals
  • Identifying the steps of atrophy related to insulin-resistance, proteolysis and cell death
    • We use a murine model of muscle atrophy that is induced by cancer cachexia where the cachexia appears to involve early alterations of insulin-mediated metabolism and inflammation that contribute to diminished energy substrate and compromised function of skeletal muscle

Experience

  • 2008 – Present: Professor, Human Nutrition, The Ohio State University, Columbus, OH
  • 2002 – Present: Carol S. Kennedy Endowed Professorship of Human Nutrition, The Ohio State University, Columbus, OH
  • 2009 – Present: Adjunct Professor, Division of Environmental Health, College of Public Health, The Ohio State University, Columbus, OH
  • 2004 – Present: Adjunct Professor, Division of Endocrinology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH
  • 2002 – 2008: Associate Professor, Human Nutrition, The Ohio State University, Columbus, OH
  • 2000 – 2002: Associate Member, Department of Molecular Medicine, Northwest Hospital, Seattle, WA
  • 1998 – 2000: Associate Professor with Tenure, Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana
  • 1994 – 1998: Assistant Professor, Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana
  • 1992 – 1994: Assistant Professor, Department of Health and Human Development, Montana State University, Bozeman, Montana

Honors

  • 2012: College of Education and Human Ecology, Award for Distinguished Scholarship, The Ohio State University, Columbus, OH
  • 2012: Most Cited Paper [1] (ranked 17th) in 70-year history of Nutrition Reviews journal, International Life Sciences Institute (ILSI), Washington, DC ·    
  • 2011: Elected Fellow, American Association for the Advancement of Science (AAAS), Washington, DC
  • 2011: Visiting Professorship, Taipei Medical University, Taipei, Taiwan
  • 2007: Mentor, Director’s Award for Excellence in Student Research, OARDC, The Ohio State University, Columbus, OH
  • 2004: Dean’s Award for Research, College of Human Ecology, The Ohio State University, Columbus, OH
  • 2003: Hot Paper [2], ESI Essential Scientific Indicators, Most Cited Paper for Agricultural Sciences for Third Quarter, Thomson Reuters
  • 2000: E.L.R Stokstad Award for Outstanding Research, American Society for Nutritional Sciences (ASNS), Presented at Experimental Biology, April 16, 2000, San Diego, CA
  • 1999: Outstanding Young Professional Award for 1999, Texas Exes in Human Ecology, University of Texas, Austin, TX
  • 1993: Most Influential Teacher, College of Education, Health and Human Development, Montana State University, Bozeman, MT
  • 1992: Pre-Doctoral Training Grant in Toxicology, NIEHS, NIH, University of Texas, Austin, TX

[1] Belury, MA. Conjugated dienoic linoleate:  A unique chemoprotective polyunsaturated fatty acid.  Nutr Rev 1995; 53: 83-89
[2] Belury, MA. Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annu Rev Nutr 2002; 22: 505-531

Grants

  • Bioavailability and Activity of Dietary Naringenin as a Chemopreventive Agent(Aug 2012 – July 2014): The goal of this study is to determine the uptake and effects of naringenin on metabolism and markers of cell proliferation in mammary tissue of mice. Martha Belury, PI, Organization:  NCI, NIH, R03 1R03CA162551, Role: PI, 7%
  • Pilot study:  Reducing visceral adipose tissue in postmenopausal women with dietary oils (Apr 2011 – Mar 2014): The goals of this grant are to develop and validate the MRI as an instrument to measure changes of visceral adipose tissue in women after supplementation with dietary safflower oil. Martha Belury, PI, Internal:  OARDC (Internal Multi-disciplinary), Role: PI, 0%
  • Testing fish oil-derivatives in healing of chronic venous leg ulcers (Jan 2012 – Dec 2013): Determine the effect of supplementing fish oil to people with leg ulcers will aid in wound healing. Jodi McDaniel, PI, Agency: NINR, NIH, 1R21NR012803, Role:  Co-I, 5%
  • Omega-3 fatty acids & psychoeducational psychotherapy for childhood depression (Jan 2011 – Jan 2014): We will test the feasibility and effect of omega3 fatty acid supplementation on behavior and depression in children with bipolar disorder. Mary Fristad, PI, Agency: NIMH, NIH, R34 MH085875-01A2, Role:  Co-I, 3%
  • Training competitive nutrition scientists from underrepresented backgrounds in 21st century skills to stem the tide of childhood obesity (Jan 2011-Jan 2014): This training grant will be used for improving our methods for recruiting, retaining and graduating competitive students that also are students of under-represented backgrounds in nutritional sciences. Mark Failla, PI, Agency: NIFA, USDA, Role: Co-I, 0%
  • Fatigue, depression, and inflammation in cancer survivors: A prospective study (Oct 2009 – Feb 2014): The objective of this study is to determine the correlation of depression with inflammation as predictive markers for survival of therapy and prevention of recurrence in women recovering from breast cancer. Janice Kiecolt-Glaser, PI, Agency:  NCI / NIH, Role: Co-I, 5%

Presentations

  • Invited speaker, Putting out the fire:  Evidence that linoleic acid does not fuel inflammation.  ASN annual meeting, Experimental Biology ’13, Boston, MA, April 22, 2013
  • Keynote speaker, Metabolic consequences of an unemployed adipocyte. Celebratory conference honoring the retirement for Susan M. Fischer, PhD, Professor, MD Anderson and University of Texas, Smithville, TX, Oct 26, 2012
  •  Invited speaker, Using dietary oils to target the metabolic syndrome.  Department of Pediatrics, Louisiana State University, Shreveport, LA, Dec 13, 2011

Selected Publications

  • Purushotham A, Wendel AA, Liu, L-F, Belury MA.  Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice.  J Lipid Res 48: 444-452, 2007
  • Wendel AA, Liu, LF, Purushotham A, Belury MA.  Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J Lipid Res 49: 98-106, 2008
  • Purushotham A,Tian M, Belury MA. Citrus fruit flavonoid naringenin suppresses glucose output from hepatic cells. Mol Nutr Food Res 53(2):300-307, 2008
  • Norris LE, Collene AL, Asp ML, Hsu JC, Liu LF, Richardson JR, Li D, Bell D, Osei K, Jackson RD, Belury MA, Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus, Am J Clin Nutr. 90:468-476, 2009.
  • Asp ML, Tian M, Wendel AA, Belury MA, Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice, Int. J. Cancer. 126:756-763, 2010
  • Tian M, Yoshinori N, Asp ML, Stout MB, Reiser PJ, Belury MA. Cardiac alterations in cancer-induced cachexia in mice. International Journal of Oncology 2010; 37(2):347-53
  • Casagrande G, Belury MA, LeJeune J, Medeiros LC.  Registered dietitian's personal beliefs and characteristics predict their teaching or intention to teach fresh vegetable food safety. Appetite 2011; 56(2):469-75
  • Tian M, Kliewer KL, Asp ML, Stout MB, Belury MA. c9t11-CLA rich oil fails to attenuate wasting in colon-26 tumor-induced late stage cancer cachexia in male CD2F1 mice.  Molecular Nutrition & Food Research 2011; 55(2):268-77
  • Asp ML, Norris LE, Collene AL, Cole R, Stout MB, Yu S-Z, Hsu JC, Belury MA.   Time-to-effect analyses of improvement of glycemia by dietary safflower oil in obese, post-menopausal women with type 2 diabetes. Clin Nutr 2011; 30 (4) 443-9
  • Stout MB, Liu L-F, Belury MA. Hepatic steatosis by dietary conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C epsilon in mice.  Mol Nutr Food Res 2011; 55(7): 1010-7
  • Tian M, Asp ML, Kliewer KL, Belury MA. Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. Int J Oncol 2011;  39 (5): 1321-6
  • Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 Supplementation Lowers Inflammation and Anxiety in Medical Students: A Randomized Controlled Trial.  Brain Behav Immun 2011; 25(8): 1725-34
  • Asp ML, Tian M, Kliewer KL, Belury MA. Rosiglitazone delayed weight loss and anorexia while attenuating adipose depletion in mice with cancer cachexia.  Cancer Biol Ther 2012;12(11):957-65
  • Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun 2012; 26:988-95
  • McDaniel JC, Belury MA. Are young adults following the dietary guidelines for Americans? Nurse Pract 2012; 37(5):1-9
  • Asp ML, Collene AL, Richardson JR, Droll KR, Belury MA. Dietary protein and beef consumption predict for markers of muscle mass and nutrition status in older adults. J Nutr Health Aging 2012; 16(9):784-90
  • Orchard TS, Ing SW, Lu B, Belury MA, Johnson K, Wactawski-Wende J, Jackson RD. The association of red blood cell n-3 and n-6 fatty acids to dietary fatty acid intake, bone mineral density and hip fracture risk in the Women's Health InitiativeJ Bone Miner Res 2013; 28(3):505-15
  • Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun 2013; 28:16-24
  • Kutay H, Klepper C, Wang B, Hsu SH, Datta J, Yu L, Zhang X, Majumder S, Motiwala T, Khan N, Belury M, McClain C, Jacob S, Ghoshal K.  Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. PLoS One 2012; 7(8):e41949
  • Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SK. The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. Mol Nutr Food Res. 2013;57(2):320-7